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A Phase 1, Open-Label, Multicentre, Non-Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of AZD4573, a Potent and Selective CDK9 Inhibitor, in Subjects With Relapsed or Refractory Haematological Malignancies

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Trial Profile

A Phase 1, Open-Label, Multicentre, Non-Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of AZD4573, a Potent and Selective CDK9 Inhibitor, in Subjects With Relapsed or Refractory Haematological Malignancies

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 19 Jan 2023

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At a glance

  • Drugs AZD-4573 (Primary)
  • Indications Acute myeloid leukaemia; B-cell lymphoma; Chronic lymphocytic leukaemia; Chronic myelomonocytic leukaemia; Diffuse large B cell lymphoma; Haematological malignancies; Hairy cell leukaemia; Mantle-cell lymphoma; Multiple myeloma; Myelodysplastic syndromes; Non-Hodgkin's lymphoma; Precursor cell lymphoblastic leukaemia-lymphoma; Richter's syndrome; T-cell lymphoma
  • Focus Adverse reactions; First in man
  • Sponsors AstraZeneca

    • Most Recent Events

    • 13 Dec 2022 Results (At data cutoff Sept 30, 2021) assessing the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary antitumor activity of AZD4573 in patients (pts) with relapsed or refractory hematological malignancies, presented at the 64th American Society of Hematology Annual Meeting and Exposition.
    • 21 Oct 2021 Status changed from recruiting to completed.
    • 26 Aug 2021 Planned End Date changed from 1 Feb 2022 to 2 Mar 2022.

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