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Randomised, Multicentre, Phase II Pilot Study to Assess the Efficacy and Safety of Treatment With FOLFIRI-aflibercept Compared to Initial Treatment With FOLFIRI-aflibercept (for 6 Cycles) Followed by Maintenance With 5FU-aflibercept, in an Elderly Population With Metastatic Colorectal Cancer (mCRC) After Failure of an Oxaliplatin-based Regimen

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Randomised, Multicentre, Phase II Pilot Study to Assess the Efficacy and Safety of Treatment With FOLFIRI-aflibercept Compared to Initial Treatment With FOLFIRI-aflibercept (for 6 Cycles) Followed by Maintenance With 5FU-aflibercept, in an Elderly Population With Metastatic Colorectal Cancer (mCRC) After Failure of an Oxaliplatin-based Regimen

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 05 Dec 2023

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At a glance

  • Drugs Aflibercept (Primary) ; Fluorouracil; Folinic acid; Irinotecan
  • Indications Adenocarcinoma; Colon cancer; Colorectal cancer; Rectal cancer
  • Focus Therapeutic Use
  • Acronyms AFEMA

    • Most Recent Events

    • 24 Oct 2023 Results assessing efficacy and safety of FOLFIRI-aflibercept Compared to Initial Treatment With FOLFIRI-aflibercept, presented at the 48th European Society for Medical Oncology Congress.
    • 24 Oct 2023 Primary endpoint (Progression-free survival) has been met, according to results presented at the 48th European Society for Medical Oncology Congress.
    • 12 Apr 2023 Status changed from active, no longer recruiting to completed.

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