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A Phase Ib/II, Open-Label, Multicenter, Randomized, Umbrella Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (Morpheus-Gastric Cancer)

Trial Profile

A Phase Ib/II, Open-Label, Multicenter, Randomized, Umbrella Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (Morpheus-Gastric Cancer)

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 01 Nov 2019

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At a glance

  • Drugs Atezolizumab (Primary) ; Cobimetinib (Primary) ; Hyaluronidase (Primary) ; Linagliptin (Primary) ; Motixafortide (Primary) ; Fluorouracil; Folinic acid; Oxaliplatin; Paclitaxel; Ramucirumab
  • Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms MORPHEUS-GC; UMBRELLA
  • Sponsors Roche
  • Most Recent Events

    • 19 Jan 2019 Trial design of the three GI-specific MORPHEUS trials, presented at the 2019 Gastrointestinal Cancers Symposium
    • 05 Jun 2018 Trial design for two studies (MORPHEUS-GC and MORPHEUS-PDAC) presented at the 54th Annual Meeting of the American Society of Clinical Oncology.
    • 18 Jan 2018 Trial design presented at the Gastrointestinal Cancers Symposium.
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