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A Phase 1/2, Open-Label, Multicenter, Dose Escalation and Efficacy Study of mRNA-2416, a Lipid Nanoparticle Encapsulated mRNA Encoding Human OX40L, for Intratumoral Injection Alone or in Combination With Durvalumab for Patients With Advanced Malignancies

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A Phase 1/2, Open-Label, Multicenter, Dose Escalation and Efficacy Study of mRNA-2416, a Lipid Nanoparticle Encapsulated mRNA Encoding Human OX40L, for Intratumoral Injection Alone or in Combination With Durvalumab for Patients With Advanced Malignancies

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 02 Aug 2024

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At a glance

  • Drugs Durvalumab (Primary) ; MRNA-2416 (Primary)
  • Indications Carcinoma; Fallopian tube cancer; Lymphoma; Ovarian cancer; Peritoneal cancer; Solid tumours
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Sponsors Moderna Therapeutics

    • Most Recent Events

    • 07 Jul 2022 Status changed from active, no longer recruiting to discontinued.
    • 12 Aug 2021 Planned End Date changed from 22 Mar 2023 to 20 Sep 2022.
    • 12 Aug 2021 Planned primary completion date changed from 22 Mar 2023 to 20 Sep 2022.

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