Trial Profile

A Multicenter, Phase I/II Trial of Anastrozole, Palbociclib, Trastuzumab and Pertuzumab in HR-positive, HER2-positive Metastatic Breast Cancer

Status: Active, no longer recruiting

Phase of Trial: Phase I/II

Latest Information Update: 05 Aug 2026

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At a glance

Drugs Anastrozole (Primary) ; Palbociclib (Primary) ; Pertuzumab (Primary) ; Trastuzumab (Primary)
Indications Advanced breast cancer; HER2 positive breast cancer; Male breast cancer
Focus Adverse reactions; Therapeutic Use
Acronyms ASPIRE

Most Recent Events

29 Jul 2026 Planned End Date changed from 31 Dec 2026 to 31 Dec 2027.
29 Jul 2026 Planned primary completion date changed from 31 Jul 2026 to 31 Jul 2027.
18 Jul 2025 Planned End Date changed from 31 Dec 2025 to 31 Dec 2026.

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