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A Phase 3b, Multicenter, Prospective, Randomized, Double Blind, Placebocontrolled Study to Reduce Incidence of Pre-dialysis Hyperkalemia With Sodium Zirconium Cyclosilicate (DIALIZE)

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Trial Profile

A Phase 3b, Multicenter, Prospective, Randomized, Double Blind, Placebocontrolled Study to Reduce Incidence of Pre-dialysis Hyperkalemia With Sodium Zirconium Cyclosilicate (DIALIZE)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 07 Dec 2021

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At a glance

  • Drugs Zirconium silicate (Primary)
  • Indications Hyperkalaemia
  • Focus Registrational; Therapeutic Use
  • Acronyms DIALIZE
  • Sponsors AstraZeneca
  • Most Recent Events

    • 24 Nov 2020 According to an AstraZeneca media release, based on the data from this study National Medical Products Administration (NMPA) has approved a dosing label update in China for Lokelma (sodium zirconium cyclosilicate) to include patients with hyperkalaemia on chronic haemodialysis.
    • 20 Oct 2020 According to an AstraZeneca media release, new sub-analyses of this Phase IIIb trial will be presented at the at ASN Kidney Week 2020 Reimagined, taking place virtually from 22th-25th Oct 2020.
    • 05 Jun 2020 According to an AstraZeneca media release, ERA-EDTA 2020 Virtual Congress abstracts will be made available online on Friday 5 June 2020 in an abstract supplement to be published with the June issue of the Nephrology Dialysis Transplantation Journal

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