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A phase Ib/IIa pilot trial of the oral Hedgehog Signalling Inhibitor, Glasdegib, in Patients with sclerotic chronic graft-versus-host disease refractory to second-line treatment

Trial Profile

A phase Ib/IIa pilot trial of the oral Hedgehog Signalling Inhibitor, Glasdegib, in Patients with sclerotic chronic graft-versus-host disease refractory to second-line treatment

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 05 Mar 2024

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At a glance

  • Drugs Glasdegib (Primary)
  • Indications Graft-versus-host disease
  • Focus Adverse reactions
  • Acronyms GETH trial
  • Most Recent Events

    • 13 Dec 2022 Results from two clinical studies: NCT03415867 and NCT04111497 assessing safety and efficacy of glasdegib in adult patients with refractory scGVHD at data cutoff of 12-months presented at the 64th American Society of Hematology Annual Meeting and Exposition
    • 21 Nov 2021 Status changed from active, no longer recruiting to completed.
    • 17 Jun 2021 Results presented at the 26th Congress of the European Haematology Association
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