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A phase 1b/2, open-label, multicenter, randomized clinical trial to evaluate the safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of PEGPH20 in combination with atezolizumab compared with the standard chemotherapy regimens in patients with previously treated, locally advanced unresectable or metastatic gastric or gastroesophageal junction cancer

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Trial Profile

A phase 1b/2, open-label, multicenter, randomized clinical trial to evaluate the safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of PEGPH20 in combination with atezolizumab compared with the standard chemotherapy regimens in patients with previously treated, locally advanced unresectable or metastatic gastric or gastroesophageal junction cancer

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 26 Oct 2017

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At a glance

  • Drugs Atezolizumab (Primary) ; Hyaluronidase (Primary)
  • Indications Gastric cancer; Oesophageal cancer
  • Focus Adverse reactions; Pharmacokinetics
  • Sponsors Genentech

    • Most Recent Events

    • 26 Oct 2017 New trial record
    • 24 Oct 2017 According to a Halozyme Therapeutics media release, the study will be conducted in the U.S., as well as countries outside the U.S. The overall analysis plan includes a retrospective analysis of the HA-high population identified using the Ventana HA companion diagnostic assay.
    • 24 Oct 2017 According to a Halozyme Therapeutics media release, first gastric cancer patient has been dosed in the trial.

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