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An Open-Label, Dose Escalation and Dose Expansion Trial Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Orally Administered CA-4948 in Patients With Relapsed or Refractory Primary Central Nervous System Lymphoma

Trial Profile

An Open-Label, Dose Escalation and Dose Expansion Trial Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Orally Administered CA-4948 in Patients With Relapsed or Refractory Primary Central Nervous System Lymphoma

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 14 Feb 2024

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At a glance

  • Drugs Emavusertib (Primary) ; Ibrutinib (Primary)
  • Indications Acute myeloid leukaemia; B-cell lymphoma; Chronic lymphocytic leukaemia; CNS cancer; Diffuse large B cell lymphoma; Haematological malignancies; Lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms TakeAim Lymphoma
  • Sponsors Curis
  • Most Recent Events

    • 08 Feb 2024 According to a Curis media release, company working open additional clinical sites in the US and Europe for both the TakeAim Leukemia and Lymphoma studies.
    • 08 Feb 2024 According to a Curis media release, updated clinical data from the on-going combination study of emavusertib with ibrutinib in the second half of 2024.
    • 12 Dec 2023 Trial design presented at the 65th American Society of Hematology Annual Meeting and Exposition
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