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An Open-Label, Multicenter, Phase 1/2 Study of RP1 as a Single Agent and in Combination With PD1 Blockade in Patients With Solid Tumors [IGNYTE]

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Trial Profile

An Open-Label, Multicenter, Phase 1/2 Study of RP1 as a Single Agent and in Combination With PD1 Blockade in Patients With Solid Tumors [IGNYTE]

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 18 Feb 2026

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At a glance

  • Drugs Nivolumab (Primary) ; Vusolimogene oderparepvec (Primary)
  • Indications Basal cell cancer; Bladder cancer; Carcinoma; Haemangiosarcoma; Head and neck cancer; Malignant melanoma; Merkel cell carcinoma; Non-small cell lung cancer; Skin cancer; Solid tumours; Squamous cell cancer; Urogenital cancer; Uveal melanoma
  • Focus Adverse reactions; First in man; Registrational; Therapeutic Use
  • Acronyms IGNYTE
  • Sponsors Replimune

Most Recent Events

  • 13 Feb 2026 Planned primary completion date changed from 1 Dec 2025 to 1 Jun 2028.
  • 17 Dec 2025 Status changed from recruiting to active, no longer recruiting.
  • 08 Nov 2025 According to a Replimune media release, the IGNYTE phase 2 cohort enrolled 140 patients with stage IIIB-IV cutaneous melanoma and confirmed progression on anti-PD1- based therapy for > 8 weeks as the last prior treatment.

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