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A Phase 1, Randomized, Observer-Blind, Placebo-Controlled, Safety, Immunogenicity, and Dose Ranging Study of Purified Inactivated Zika Virus Vaccine (PIZV) Candidate in Flavivirus Naive and Primed Healthy Adults Aged 18 to 49 Years

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Trial Profile

A Phase 1, Randomized, Observer-Blind, Placebo-Controlled, Safety, Immunogenicity, and Dose Ranging Study of Purified Inactivated Zika Virus Vaccine (PIZV) Candidate in Flavivirus Naive and Primed Healthy Adults Aged 18 to 49 Years

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 15 Dec 2022

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At a glance

  • Drugs TAK-426 (Primary)
  • Indications Zika virus infection
  • Focus Adverse reactions; Pharmacodynamics
  • Sponsors Takeda

    • Most Recent Events

    • 09 Dec 2022 Results assessing safety and persistence of immunity up to 2 years after primary vaccination with 10 microgm TAK-426, the highest dose, and compare neutralizing antibody responses with those observed after natural infection published in the Journal of Infectious Diseases
    • 11 Dec 2020 Status changed from active, no longer recruiting to completed.
    • 23 Nov 2019 According to a Takeda media release, data from this study were presented at the American Society of Tropical Medicine and Hygiene (ASTMH) 68th Annual Meeting.

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