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A Randomised, Double-Blind, Placebo-Controlled, International, Multicentre, Phase III Study to Investigate the Efficacy and Safety of Ticagrelor and ASA Compared with ASA in the Prevention of Stroke and Death in Patients with Acute Ischaemic Stroke or Transient Ischaemic Attack - THALES - Acute STroke or Transient IscHaemic Attack Treated with TicAgreLor and ASA for PrEvention of Stroke and Death

Trial Profile

A Randomised, Double-Blind, Placebo-Controlled, International, Multicentre, Phase III Study to Investigate the Efficacy and Safety of Ticagrelor and ASA Compared with ASA in the Prevention of Stroke and Death in Patients with Acute Ischaemic Stroke or Transient Ischaemic Attack - THALES - Acute STroke or Transient IscHaemic Attack Treated with TicAgreLor and ASA for PrEvention of Stroke and Death

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 01 Jul 2022

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At a glance

  • Drugs Ticagrelor (Primary) ; Aspirin
  • Indications Stroke
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms THALES
  • Sponsors AstraZeneca
  • Most Recent Events

    • 18 Apr 2022 Results of an exploratory analysis assessing the cumulative incidence of irreversible efficacy and safety outcomes at different timepoints during the 30-day treatment period published in the Neurology
    • 03 Sep 2021 Results evaluating benefits of 30-day treatment with ticagrelor-aspirin in patients with mild-moderate ischemic stroke or high-risk TIA,published in the Stroke
    • 09 Jul 2021 Results of an exploratory post hoc analysis to compare patients with moderate stroke with those of sever stroke among ischemic stroke patients published in the JAMA Neurology
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