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A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MEDI2452 (PB2452) With and Without Ticagrelor Pretreatment in Healthy Volunteers

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Trial Profile

A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MEDI2452 (PB2452) With and Without Ticagrelor Pretreatment in Healthy Volunteers

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 05 Nov 2021

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At a glance

  • Drugs Bentracimab (Primary) ; Ticagrelor
  • Indications Haemorrhage
  • Focus Adverse reactions; First in man; Pharmacodynamics; Pharmacokinetics
  • Sponsors PhaseBio Pharmaceuticals

    • Most Recent Events

    • 30 Mar 2020 According to a PhaseBio Pharmaceuticals media release, the U.S. Food and Drug Administration granted Breakthrough Therapy designation for PB2452, based on the data from this trial.
    • 21 Mar 2020 Results presented at the 121st Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics
    • 17 Mar 2019 According to a PhaseBio Pharmaceuticals media release, results from this study were presented in a featured clinical research session at the American College of Cardiology's 68th Annual Scientific Session.

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