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A Multicenter, Randomized, Double-Blind, Placebo- and Active-Controlled, Cross-over Phase 2 Study of Continuous 5-Hour Intravenous Infusions of BMS-986231 in Patients With Heart Failure and Impaired Systolic Function

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Trial Profile

A Multicenter, Randomized, Double-Blind, Placebo- and Active-Controlled, Cross-over Phase 2 Study of Continuous 5-Hour Intravenous Infusions of BMS-986231 in Patients With Heart Failure and Impaired Systolic Function

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 20 Jun 2022

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At a glance

  • Drugs Cimlanod (Primary) ; Nitroglycerin
  • Indications Heart failure
  • Focus Therapeutic Use
  • Sponsors Bristol-Myers Squibb

    • Most Recent Events

    • 23 Feb 2021 Results comparing effects of the HNO donor cimlanod (BMS-986231) with those of nitroglycerin (NTG) or placebo on cardiac function in patients with chronic heart failure with reduced ejection fraction (HFrEF) published in the European Journal of Heart Failure
    • 30 Mar 2020 Primary endpoint has been met. (Left Ventricle Stroke Volume Index (SVI))
    • 30 Mar 2020 Results presented at the 2020 Annual Scientific Session of the American College of Cardiology and World Congress of Cardiology
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