Trial Profile

A Phase 3 Randomized, Double-Blind Trial of Pembrolizumab (MK-3475) in Combination With Epacadostat (INCB024360) or Placebo in Participants With Cisplatin-ineligible Urothelial Carcinoma (KEYNOTE-672/ECHO-307)

Status: Completed

Phase of Trial: Phase III

Latest Information Update: 25 Sep 2025

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At a glance

Drugs Epacadostat (Primary) ; Pembrolizumab (Primary)
Indications Bladder cancer; Carcinoma; Pelvic cancer; Renal cancer; Ureteral neoplasms; Urethral cancer; Urogenital cancer
Focus Registrational; Therapeutic Use
Acronyms KEYNOTE-672/ECHO-307
Sponsors Incyte Corporation

25 Jul 2024 According to a Results published in the BMC Cancer, enrollment was stopped early due to emerging data from the phase III ECHO-301/KEYNOTE-252 study
25 Jul 2024 Results published in the BMC Cancer
09 Dec 2021 New source identified and integrated (Japan Pharmaceutical Information Center - Clinical Trials Information record: JapicCTI183884).

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