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An Open-label, Single Arm, Phase 2 Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis

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Trial Profile

An Open-label, Single Arm, Phase 2 Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 17 Jun 2025

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At a glance

  • Drugs Avapritinib (Primary)
  • Indications Mast Cell Leukemia; Systemic mastocytosis
  • Focus Registrational; Therapeutic Use
  • Acronyms PATHFINDER
  • Sponsors Blueprint Medicines

Most Recent Events

  • 12 Jun 2025 According to a Blueprint Medicines media release, data from the trial will be reported at the 2025 European Hematology Association (EHA2025) Hybrid Congress, being held June 12 to 15 in Milan, Italy, and the European Academy of Allergy and Clinical Immunology (EAACI) Congress 2025, being held June 13 to 16 in Glasgow, United Kingdom.
  • 30 Apr 2025 Status changed from active, no longer recruiting to completed.
  • 07 Dec 2024 According to a Blueprint Medicines media release, data from this trial will be presented at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition, taking place December 7-10 in San Diego.

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