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An Open-Label Phase 2 Study to Evaluate PT2977 for the Treatment of Von Hippel Lindau Disease-Associated Renal Cell Carcinoma

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Trial Profile

An Open-Label Phase 2 Study to Evaluate PT2977 for the Treatment of Von Hippel Lindau Disease-Associated Renal Cell Carcinoma

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 26 Nov 2024

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At a glance

  • Drugs Belzutifan (Primary)
  • Indications Haemangioblastoma; Neuroendocrine tumours; Pancreatic cancer; Renal cell carcinoma; Von Hippel-Lindau disease
  • Focus Registrational; Therapeutic Use
  • Acronyms LITESPARK-004
  • Sponsors Merck Sharp & Dohme Corp.; Peloton Therapeutics
  • Most Recent Events

    • 22 Nov 2024 Results published in the Merck & Co Media Release.
    • 22 Nov 2024 According to a Merck & Co Media Release, the National Medical Products Administration (NMPA) in China has approved WELIREG (belzutifan), for the treatment of adult patients with von Hippel-Lindau (VHL) disease who require therapy for associated renal cell carcinoma (RCC), central nervous system (CNS) hemangioblastomas or pancreatic neuroendocrine tumors (pNET), not requiring immediate surgery.
    • 01 Nov 2024 Results assessing the efficacy of belzutifan in participants with von Hippel-Lindau disease-associated retinal hemangioblastomas published in the Ophthalmology

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