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Phase 1, Two-part, Multicenter, Open-label, Multiple Dose, First-in-human Study of DS-1062a in Subjects With Advanced Solid Tumors (TROPION-PanTumor01)

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Trial Profile

Phase 1, Two-part, Multicenter, Open-label, Multiple Dose, First-in-human Study of DS-1062a in Subjects With Advanced Solid Tumors (TROPION-PanTumor01)

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 06 Mar 2024

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At a glance

  • Drugs Datopotamab deruxtecan (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; Bladder cancer; Carcinoma; Cervical cancer; Colorectal cancer; Endometrial cancer; Gastric cancer; Head and neck cancer; HER2 negative breast cancer; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Pancreatic cancer; Prostate cancer; Renal cell carcinoma; Small cell lung cancer; Solid tumours; Squamous cell cancer; Triple negative breast cancer; Urogenital cancer
  • Focus Adverse reactions; First in man; Proof of concept
  • Acronyms TROPION-PanTumor01
  • Sponsors AstraZeneca; Daiichi Sankyo Company

    • Most Recent Events

    • 27 Jan 2024 Preliminary Results (At data cutoff (May 18, 2023), n=18) assessing safety and efficacy of Datopotamab deruxtecan in locally advanced/metastatic urothelial cancer presented at the 2024 Genitourinary Cancers Symposium
    • 15 Jun 2023 Planned number of patients changed from 770 to 890.
    • 19 Apr 2023 Results from substudy analyzing association between stomatitis and treatment efficacy of datopotamab deruxtecan, presented at the 114th Annual Meeting of the American Association for Cancer Research

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