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A Phase I/II Trial to Evaluate the Safety and Tolerability of Clazakizumab (Anti-IL-6 Monoclonal) to Eliminate Donor Specific HLA Antibodies (DSAs) and Improve Transplant Rates in Highly-HLA Sensitized Patients Awaiting Renal Transplant

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A Phase I/II Trial to Evaluate the Safety and Tolerability of Clazakizumab (Anti-IL-6 Monoclonal) to Eliminate Donor Specific HLA Antibodies (DSAs) and Improve Transplant Rates in Highly-HLA Sensitized Patients Awaiting Renal Transplant

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 18 Mar 2024

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At a glance

  • Drugs Clazakizumab (Primary) ; Alemtuzumab; Mycophenolate mofetil; Prednisone; Tacrolimus
  • Indications Renal transplant rejection
  • Focus Adverse reactions; Therapeutic Use

    • Most Recent Events

    • 12 Mar 2024 Planned End Date changed from 30 Dec 2024 to 30 Jul 2025.
    • 12 Mar 2024 Planned primary completion date changed from 30 Dec 2024 to 30 Jul 2025.
    • 10 Mar 2023 Planned End Date changed from 30 Dec 2023 to 30 Dec 2024.

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