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A study evaluating the effect of new formulation, food or a proton pump inhibitor on the relative bioavailability of the Glasdegib in healthy volunteers.

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Trial Profile

A study evaluating the effect of new formulation, food or a proton pump inhibitor on the relative bioavailability of the Glasdegib in healthy volunteers.

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 02 Jan 2018

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At a glance

  • Drugs Glasdegib (Primary) ; Rabeprazole (Primary) ; Glasdegib
  • Indications Acute myeloid leukaemia; Cancer; Chronic myeloid leukaemia; Chronic myelomonocytic leukaemia; Colorectal cancer; Graft-versus-host disease; Haematological malignancies; Myelodysplastic syndromes; Myelofibrosis; Non-small cell lung cancer
  • Focus Pharmacokinetics
  • Sponsors Pfizer
  • Most Recent Events

    • 02 Jan 2018 New trial record
    • 01 Dec 2017 Primary endpoint (Bioavailability of Formulation A and Formulation B relative to the current diHCl-based reference formulation.) has been met as per the results published in the Cancer Chemotherapy and Pharmacology
    • 01 Dec 2017 Results published in the Cancer Chemotherapy and Pharmacology

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