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A Phase IIb, Clinical Trial to Study the Safety and Efficacy of Pembrolizumab (MK-3475) in Combination With TS-1+Cisplatin or TS-1+Oxaliplatin as a First Line Chemotherapy in Participants With Advanced or Recurrent Gastric Cancer (KEYNOTE-659)

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Trial Profile

A Phase IIb, Clinical Trial to Study the Safety and Efficacy of Pembrolizumab (MK-3475) in Combination With TS-1+Cisplatin or TS-1+Oxaliplatin as a First Line Chemotherapy in Participants With Advanced or Recurrent Gastric Cancer (KEYNOTE-659)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 04 Dec 2023

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At a glance

  • Drugs Pembrolizumab (Primary) ; Cisplatin; Gimeracil/oteracil/tegafur; Oxaliplatin
  • Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
  • Focus Therapeutic Use
  • Acronyms KEYNOTE-659
  • Sponsors Merck Sharp & Dohme

    • Most Recent Events

    • 01 Aug 2022 Results of cohort 1 and cohort 2 assessing the efficacy and safety of first-line pembrolizumab plus S-1 and oxaliplatin (cohort 1) or S-1 and cisplatin (SP) (cohort 2) for advanced gastric/gastroesophageal junction (G/GEJ) cancer in Japan, published in the Cancer Science.
    • 03 Jun 2021 Status changed from active, no longer recruiting to completed.
    • 16 Feb 2021 Planned End Date changed from 5 Nov 2021 to 17 May 2021.
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