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A Double-blind, Randomized, Parallel Group, Phase IV Study to Investigate the Effects of DAPAgliflozin on CARDiac Substrate Uptake, Myocardial Efficiency and Myocardial Contractile Work in Type 2 Diabetes Patients

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Trial Profile

A Double-blind, Randomized, Parallel Group, Phase IV Study to Investigate the Effects of DAPAgliflozin on CARDiac Substrate Uptake, Myocardial Efficiency and Myocardial Contractile Work in Type 2 Diabetes Patients

Status: Completed
Phase of Trial: Phase IV

Latest Information Update: 02 Nov 2023

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At a glance

  • Drugs Dapagliflozin (Primary)
  • Indications Type 2 diabetes mellitus
  • Focus Pharmacodynamics
  • Acronyms DAPACARD
  • Sponsors AstraZeneca

    • Most Recent Events

    • 06 Oct 2023 Results assessing the effects of dapagliflozin on tissue fatty acid metabolism in subjects with type 2 diabetes (T2D) by using positron emission tomography presented at the 59th Annual Meeting of the European Association for the Study of Diabetes
    • 17 Oct 2021 Results of an analysis of a mechanistic mathematical model of cardiorenal physiology was used to quantify the influence of established natriuretic/diuretic effects of SGLT2i on cardiac function (myocardial efficiency and global longitudinal strainpublished in the Journal of Clinical Pharmacology
    • 01 Jul 2021 Primary endpoint (Global longitudinal strain of the left ventricle (GLSLV)) has not been met.

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