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A Single-center, Open-label, One-sequence, Two-treatment Study to Investigate the Effect of Macitentan at Steady State on the Pharmacokinetics of Riociguat in Healthy Male Subjects

Trial Profile

A Single-center, Open-label, One-sequence, Two-treatment Study to Investigate the Effect of Macitentan at Steady State on the Pharmacokinetics of Riociguat in Healthy Male Subjects

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 30 Sep 2019

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At a glance

  • Drugs Macitentan (Primary) ; Riociguat (Primary)
  • Indications Congenital heart defects; Eisenmenger complex; Heart failure; Portal hypertension; Pulmonary arterial hypertension
  • Focus Pharmacokinetics
  • Sponsors Actelion Pharmaceuticals
  • Most Recent Events

    • 24 Sep 2019 Results assessing effect of Macitentan on the pharmacokinetics of the breast cancer resistance protein substrate Rosuvastatin in healthy male subjects published in the Clinical Drug Investigation
    • 07 Feb 2018 Status changed from recruiting to completed.
    • 08 Jan 2018 Status changed from not yet recruiting to recruiting.
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