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A phase I/IIa study to investigate the safety and clinical activity of APR-246 in combination with dabrafenib in patients with BRAF V600 mutant unresectable metastatic melanoma resistant to dabrafenib /trametinib combination

Trial Profile

A phase I/IIa study to investigate the safety and clinical activity of APR-246 in combination with dabrafenib in patients with BRAF V600 mutant unresectable metastatic melanoma resistant to dabrafenib /trametinib combination

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 19 Nov 2021

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At a glance

  • Drugs Dabrafenib (Primary) ; Eprenetapopt (Primary)
  • Indications Malignant melanoma
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms EMERA
  • Sponsors Aprea Therapeutics

Most Recent Events

  • 29 Jul 2019 Status changed from active, no longer recruiting to discontinued due to difficulty in finding patients
  • 17 Sep 2018 Planned End Date changed from 1 Mar 2019 to 1 Dec 2018.
  • 17 Sep 2018 Planned primary completion date changed from 1 Feb 2019 to 1 Dec 2018.

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