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A Phase I/II, Open-Label, Dose Escalation and Cohort Expansion Study Evaluating the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD), and Therapeutic Activity of OBI-888 in Patients With Locally Advanced or Metastatic Solid Tumors.

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Trial Profile

A Phase I/II, Open-Label, Dose Escalation and Cohort Expansion Study Evaluating the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD), and Therapeutic Activity of OBI-888 in Patients With Locally Advanced or Metastatic Solid Tumors.

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 06 Dec 2024

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At a glance

  • Drugs OBI 888 (Primary)
  • Indications Advanced breast cancer; Colorectal cancer; Gastric cancer; Lung cancer; Oesophageal cancer; Pancreatic cancer; Solid tumours
  • Focus Adverse reactions
  • Sponsors OBI Pharma

    • Most Recent Events

    • 01 Dec 2024 Results (n=54) published in the Cancer Chemotherapy and Pharmacology.
    • 05 Jul 2022 According to an OBI Pharma media release, this study report is estimated to be finalized in Q4, 2022 and presented at a future medical conference.
    • 05 Jul 2022 According to an OBI Pharma media release, this trial discontinued upon completion of enrollment due to the higher antibody amount required for the OBI-888 treatment compared to the ADC, OBI-999, and an unexpected low drug yield at the large manufacturing scale, OBI-888 no longer fulfills our goal of developing cost-effective therapies for cancer patients. Compny has therefore decided to discontinue OBI-888 development.

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