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A Phase III, Randomized, Open-label Study to Evaluate Pembrolizumab as Neoadjuvant Therapy and in Combination With Standard of Care as Adjuvant Therapy for StageIII-IVA Resectable Locoregionally Advanced Head and Neck Squamous Cell Carcinoma (LA HNSCC) III

Trial Profile

A Phase III, Randomized, Open-label Study to Evaluate Pembrolizumab as Neoadjuvant Therapy and in Combination With Standard of Care as Adjuvant Therapy for StageIII-IVA Resectable Locoregionally Advanced Head and Neck Squamous Cell Carcinoma (LA HNSCC) III

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 12 Oct 2023

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At a glance

  • Drugs Pembrolizumab (Primary) ; Cisplatin
  • Indications Head and neck cancer; Squamous cell cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms KEYNOTE-689
  • Sponsors Merck Sharp & Dohme Corp.
  • Most Recent Events

    • 21 Sep 2023 Planned End Date changed from 30 Jul 2026 to 10 Sep 2026.
    • 21 Sep 2023 Planned primary completion date changed from 30 Jul 2025 to 10 Sep 2025.
    • 13 Mar 2021 This trial has been suspended in Spain, according to European Clinical Trials Database record.
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