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A Phase 1/2 Dose Escalation and Dose Expansion Study of Mecbotamab Vedotin (BA3011) Alone and in Combination With Nivolumab in Adult and Adolescent Patients 12 Years and Older With Advanced Solid Tumors

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Trial Profile

A Phase 1/2 Dose Escalation and Dose Expansion Study of Mecbotamab Vedotin (BA3011) Alone and in Combination With Nivolumab in Adult and Adolescent Patients 12 Years and Older With Advanced Solid Tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 26 Dec 2024

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At a glance

  • Drugs Mecbotamab vedotin (Primary) ; Nivolumab (Primary)
  • Indications Adenocarcinoma; Bone cancer; Malignant fibrous histiocytoma; Malignant melanoma; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer; Sarcoma; Soft tissue sarcoma; Solid tumours
  • Focus Adverse reactions; First in man; Registrational; Therapeutic Use
  • Sponsors BioAtla

    • Most Recent Events

    • 20 Dec 2024 According to a Bioatla media release, Phase 2B data in mutated KRAS (mKRAS) non-small cell lung cancer (NSCLC) is expected readout 1H 2026.
    • 14 May 2024 According to a Bioatla media release, company completed enrollment of initial 20 patients at 1.8 mg/kg 2Q3W regimen and Anticipate meeting with the FDA for guidance on the remaining portion of the potentially registrational trial in 2H 2024.
    • 17 Apr 2024 Planned number of patients changed from 120 to 300.

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