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A Phase I-II Study to Evaluate the Efficacy and Safety of Niraparib in Combination With Cabozantinib (XL184) in Patients With Advanced Urothelial Cancer After Failure to First-line Platinum-based Chemotherapy

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Trial Profile

A Phase I-II Study to Evaluate the Efficacy and Safety of Niraparib in Combination With Cabozantinib (XL184) in Patients With Advanced Urothelial Cancer After Failure to First-line Platinum-based Chemotherapy

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 03 Sep 2024

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At a glance

  • Drugs Cabozantinib (Primary) ; Niraparib (Primary)
  • Indications Renal cell carcinoma; Urogenital cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms NICARAGUA

    • Most Recent Events

    • 29 Aug 2024 Status changed from active, no longer recruiting to completed.
    • 27 Dec 2023 Planned End Date changed from 1 Oct 2025 to 1 Apr 2024.
    • 24 Oct 2023 Results of first interim analysis (n=44) assessing safety and efficacy in an expansion cohort of mUC presented at the 48th European Society for Medical Oncology Congress

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