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A Randomised, Double-blind (Sponsor Open), Placebo-controlled, Three Part Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single (in Both Fed and Fasted States) or Repeat Doses of GSK3358699 in Healthy Male Participants

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Trial Profile

A Randomised, Double-blind (Sponsor Open), Placebo-controlled, Three Part Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single (in Both Fed and Fasted States) or Repeat Doses of GSK3358699 in Healthy Male Participants

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 05 Sep 2023

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At a glance

  • Drugs GSK-3358699 (Primary)
  • Indications Rheumatoid arthritis
  • Focus Adverse reactions; First in man
  • Sponsors GlaxoSmithKline; GSK

    • Most Recent Events

    • 13 Nov 2021 Following a temporary halt to investigate cardiac-related adverse events during cohort 4, the study design was amended for cohorts 5-7, as per results published in the British Journal of Clinical Pharmacology
    • 13 Nov 2021 Results published in the British Journal of Clinical Pharmacology
    • 11 Feb 2020 Status changed from suspended to discontinued.

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