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A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Cabozantinib (XL184) in Subjects With Radioiodine-Refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy

Trial Profile

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Cabozantinib (XL184) in Subjects With Radioiodine-Refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 12 Sep 2023

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At a glance

  • Drugs Cabozantinib (Primary)
  • Indications Carcinoma; Thyroid cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms COSMIC-311
  • Sponsors Exelixis
  • Most Recent Events

    • 18 Aug 2023 This trial has been discontinued in Austria, according to the European Clinical Trials Database record.
    • 16 May 2023 Planned End Date changed from 1 Dec 2022 to 1 Dec 2023.
    • 04 Mar 2023 Results assessing population pharmacokinetic (PopPK) and exposure-response analysis of COSMIC-311 study published in the Clinical Pharmacokinetics
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