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A Phase I-II Open-label Study of Reduced Intensity-allogeneic Transplant of ECT-001 (UM171/ Fed-batch Culture System) Expanded Cord Blood in Patients With High-risk Multiple Myeloma

Trial Profile

A Phase I-II Open-label Study of Reduced Intensity-allogeneic Transplant of ECT-001 (UM171/ Fed-batch Culture System) Expanded Cord Blood in Patients With High-risk Multiple Myeloma

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 03 Feb 2025

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At a glance

  • Drugs Dorocubicel (Primary) ; Cyclophosphamide; Fludarabine
  • Indications Multiple myeloma
  • Focus Adverse reactions; Pharmacodynamics; Therapeutic Use

Most Recent Events

  • 01 Jan 2025 Results assessing the safety and feasibility of single UM171-expanded single CB unit transplantation in frontline tandem auto/allo HCT for HR/ultra-HR MM patients published in the Transplantation and Cellular Therapy
  • 10 Dec 2024 Results examining the outcome of patients with poor outcome TP53 or EVI1 anomalies who were transplanted with a single UM171 CBT during the course of phase I-II(n=1) and phase II(n=9) trial, presented at the 66th American Society of Hematology Annual Meeting and Exposition
  • 06 Feb 2024 Planned End Date changed from 23 Sep 2025 to 17 Oct 2025.

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