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A Phase 1 Multiple-Dose Study to Evaluate the Safety and Tolerability of XmAb®22841 Monotherapy and in Combination With Pembrolizumab in Subjects With Selected Advanced Solid Tumors (DUET-4)

Trial Profile

A Phase 1 Multiple-Dose Study to Evaluate the Safety and Tolerability of XmAb®22841 Monotherapy and in Combination With Pembrolizumab in Subjects With Selected Advanced Solid Tumors (DUET-4)

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 04 Apr 2023

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At a glance

  • Drugs Bavunalimab (Primary) ; Pembrolizumab (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; Anal cancer; Carcinoma; Cervical cancer; Colorectal cancer; Endometrial cancer; Fallopian tube cancer; Gastric cancer; Head and neck cancer; HER2 negative breast cancer; Liver cancer; Male breast cancer; Malignant melanoma; Nasopharyngeal cancer; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Pancreatic cancer; Penile cancer; Peritoneal cancer; Renal cell carcinoma; Small cell lung cancer; Solid tumours; Squamous cell cancer; Triple negative breast cancer; Urogenital cancer; Uveal melanoma
  • Focus Adverse reactions
  • Acronyms DUET-4
  • Sponsors Xencor

Most Recent Events

  • 29 Mar 2023 Status changed from active, no longer recruiting to completed.
  • 27 May 2022 Status changed from recruiting to active, no longer recruiting.
  • 03 May 2021 Planned End Date changed from 1 Mar 2027 to 1 Nov 2025.

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