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A Phase 1 Multiple-Dose Study to Evaluate the Safety and Tolerability of XmAb®23104 in Subjects With Selected Advanced Solid Tumors

Trial Profile

A Phase 1 Multiple-Dose Study to Evaluate the Safety and Tolerability of XmAb®23104 in Subjects With Selected Advanced Solid Tumors

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 17 Jul 2024

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At a glance

  • Drugs Ipilimumab (Primary) ; Izuralimab (Primary)
  • Indications Advanced breast cancer; Carcinoma; Cervical cancer; Colorectal cancer; Endometrial cancer; Fibroma; Gastric cancer; Head and neck cancer; Liver cancer; Malignant fibrous histiocytoma; Malignant melanoma; Multiple myeloma; Nasopharyngeal cancer; Non-small cell lung cancer; Pancreatic cancer; Renal cell carcinoma; Sarcoma; Small cell lung cancer; Soft tissue sarcoma; Solid tumours; Squamous cell cancer; Urogenital cancer
  • Focus Adverse reactions; First in man
  • Acronyms DUET-3
  • Sponsors Xencor

Most Recent Events

  • 05 Jul 2024 Status changed from active, no longer recruiting to completed.
  • 08 Feb 2024 Status changed from recruiting to active, no longer recruiting.
  • 07 Nov 2023 According to Xencor media release, the company will will stop internal development of XmAb104 due to emerging data from Phase 1 expansion cohorts not meeting efficacy criteria for advancing the program. The Company will continue to support patients currently enrolled and being treated.

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