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Preventing cognitive decline and dementia from cerebral Small Vessel Disease (Prevent-SVD): a phase II pilot, factorial, randomised, open label blinded end-point trial to investigate short-term effects of cilostazol and isosorbide mononitrate on tolerability, safety, and vascular function in patients with small vessel disease associated stroke. (Lacunar Intervention Trial 1 (LACI-1))

Trial Profile

Preventing cognitive decline and dementia from cerebral Small Vessel Disease (Prevent-SVD): a phase II pilot, factorial, randomised, open label blinded end-point trial to investigate short-term effects of cilostazol and isosorbide mononitrate on tolerability, safety, and vascular function in patients with small vessel disease associated stroke. (Lacunar Intervention Trial 1 (LACI-1))

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 21 Aug 2023

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At a glance

  • Drugs Cilostazol (Primary) ; Isosorbide mononitrate (Primary)
  • Indications Brain infarction; Cognition disorders; Dementia
  • Focus Adverse reactions
  • Acronyms LACI-1; Prevent-SVD
  • Most Recent Events

    • 15 Mar 2018 New trial record
    • 26 Jan 2018 Results assessing safety and tolerability, presented at the International Stroke Conference 2018.
    • 18 Jan 2018 Status changed from recruiting to completed.
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