A Phase I Study of Pevonedistat (MLN4924, TAK924) in Combination With Ibrutinib in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia and Non-Hodgkin Lymphoma

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 03 Feb 2025

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Drugs Ibrutinib (Primary) ; Pevonedistat (Primary)
Indications B-cell prolymphocytic leukaemia; Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
Focus Adverse reactions

29 Jan 2025 Planned End Date changed from 22 Dec 2024 to 22 Jun 2025.
29 Jan 2025 Planned primary completion date changed from 22 Dec 2024 to 22 Jun 2025.
23 Sep 2024 Planned End Date changed from 22 Jun 2024 to 22 Dec 2024.

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