Trial Profile

A Phase I Study of B-Cell Maturation Antigen (BCMA)-Specific Chimeric Antigen Receptor T Cells in Combination With JSMD194, a Small Molecule Inhibitor of Gamma Secretase, in Patients With Relapsed or Persistent Multiple Myeloma

Status: Discontinued

Phase of Trial: Phase I

Latest Information Update: 19 Feb 2025

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At a glance

Drugs Crenigacestat (Primary) ; FCARH 143 (Primary) ; Cyclophosphamide; Fludarabine
Indications Multiple myeloma
Focus Adverse reactions; First in man

04 Jan 2024 Status changed from active, no longer recruiting to discontinued.
29 Dec 2023 Status changed from suspended to active, no longer recruiting.
12 Dec 2023 Results an analysis of the bone marrow aspirates collected at enrollment and again within 12 hours of the third run in dose, presented at the 65th American Society of Hematology Annual Meeting and Exposition

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