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A Phase 2 Study of Zolbetuximab (IMAB362) as Monotherapy and in Combination With Chemotherapy and/or Immunotherapy in Subjects With Metastatic or Locally Advanced Unresectable Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma and Locoregional Gastric or GEJ Adenocarcinoma Whose Are Claudin (CLDN) 18.2 Positive

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Trial Profile

A Phase 2 Study of Zolbetuximab (IMAB362) as Monotherapy and in Combination With Chemotherapy and/or Immunotherapy in Subjects With Metastatic or Locally Advanced Unresectable Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma and Locoregional Gastric or GEJ Adenocarcinoma Whose Are Claudin (CLDN) 18.2 Positive

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 10 Jul 2026

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At a glance

  • Drugs Docetaxel (Primary) ; Fluorouracil (Primary) ; Folinic acid (Primary) ; Nivolumab (Primary) ; Oxaliplatin (Primary) ; Pembrolizumab (Primary) ; Zolbetuximab (Primary)
  • Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
  • Focus Therapeutic Use
  • Acronyms ILUSTRO
  • Sponsors Astellas Pharma Global Development

Most Recent Events

  • 18 Jun 2026 Planned End Date changed from 31 May 2027 to 30 Nov 2027.
  • 18 Jun 2026 Planned primary completion date changed from 31 Jul 2026 to 31 Dec 2026.
  • 11 Dec 2025 According to an Astellas Pharma media release, company will present data from this trial at the 2026 American Society of Clinical Oncology (ASCO) Gastrointestinal (GI) Cancers Symposium, to be held January 8-10, 2026, in San Francisco, California.

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