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A Phase II randomised trial comparing immune priming by low dose oral cyclophosphamide plus olaparib versus priming by olaparib alone, prior to combination therapy with olaparib plus durvalumab, versus single agent olaparib alone, in asymptomatic platinum-sensitive recurrent ovarian, fallopian tube or primary peritoneal cancers with homologous recombination repair defects

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Trial Profile

A Phase II randomised trial comparing immune priming by low dose oral cyclophosphamide plus olaparib versus priming by olaparib alone, prior to combination therapy with olaparib plus durvalumab, versus single agent olaparib alone, in asymptomatic platinum-sensitive recurrent ovarian, fallopian tube or primary peritoneal cancers with homologous recombination repair defects

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 18 Apr 2022

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At a glance

  • Drugs Cyclophosphamide (Primary) ; Durvalumab (Primary) ; Olaparib (Primary)
  • Indications Carcinoma; Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Focus Therapeutic Use
  • Acronyms SOLACE 2

    • Most Recent Events

    • 12 Oct 2021 Planned End Date changed from 31 Aug 2024 to 30 Jun 2025.
    • 08 Sep 2020 Status changed from suspended to recruiting.
    • 26 May 2020 Status changed from recruiting to suspended.
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