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An Open-label, Multicenter, Phase I Dose-escalation Trial of EGF816 and Trametinib in Patients With Non-small Cell Lung Cancer and Acquired EGFR p.T790M-positive Resistance to 1st or 2nd Generation EGFR TKI Therapy Remark: According to Version V02_0 of the Protocol, Patients May Also be Eligible if EGFR TKI-treatment naïve, EGFR p.T790M-negative at Progression While on EGFR TKI Therapy or After Progression While on Osimertinib Treatment

Trial Profile

An Open-label, Multicenter, Phase I Dose-escalation Trial of EGF816 and Trametinib in Patients With Non-small Cell Lung Cancer and Acquired EGFR p.T790M-positive Resistance to 1st or 2nd Generation EGFR TKI Therapy Remark: According to Version V02_0 of the Protocol, Patients May Also be Eligible if EGFR TKI-treatment naïve, EGFR p.T790M-negative at Progression While on EGFR TKI Therapy or After Progression While on Osimertinib Treatment

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 17 Jul 2019

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At a glance

  • Drugs Nazartinib (Primary) ; Trametinib (Primary)
  • Indications Non-small cell lung cancer
  • Focus Adverse reactions
  • Acronyms EATON
  • Most Recent Events

    • 04 Jun 2019 Preliminary data of safety and tolerability; results (n=1) presented at the 55th Annual Meeting of the American Society of Clinical Oncology
    • 12 Jun 2018 Status changed from active, no longer recruiting to recruiting.
    • 07 May 2018 New trial record
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