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An Open-label, Multicenter, Phase I Dose-escalation Trial of EGF816 and Trametinib in Patients With Non-small Cell Lung Cancer and Acquired EGFR p.T790M-positive Resistance to 1st or 2nd Generation EGFR TKI Therapy Remark: According to Version V02_0 of the Protocol, Patients May Also be Eligible if EGFR TKI-treatment naïve, EGFR p.T790M-negative at Progression While on EGFR TKI Therapy or After Progression While on Osimertinib Treatment

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Trial Profile

An Open-label, Multicenter, Phase I Dose-escalation Trial of EGF816 and Trametinib in Patients With Non-small Cell Lung Cancer and Acquired EGFR p.T790M-positive Resistance to 1st or 2nd Generation EGFR TKI Therapy Remark: According to Version V02_0 of the Protocol, Patients May Also be Eligible if EGFR TKI-treatment naïve, EGFR p.T790M-negative at Progression While on EGFR TKI Therapy or After Progression While on Osimertinib Treatment

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 21 Feb 2024

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At a glance

  • Drugs Nazartinib (Primary) ; Trametinib (Primary)
  • Indications Non-small cell lung cancer
  • Focus Adverse reactions
  • Acronyms EATON

    • Most Recent Events

    • 14 Feb 2024 Status changed from recruiting to completed.
    • 02 Nov 2022 Planned primary completion date changed from 15 Sep 2022 to 15 Dec 2022.
    • 15 Jun 2022 Planned End Date changed from 25 Nov 2021 to 25 Apr 2023.
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