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A Randomised, Double-Blind, Parallel-Group, Multicentre, Phase III Study to Evaluate the Effect of Ticagrelor versus Placebo in Reducing the Rate of Vaso-Occlusive Crises in Paediatric Patients with Sickle Cell Disease (HESTIA3)

Trial Profile

A Randomised, Double-Blind, Parallel-Group, Multicentre, Phase III Study to Evaluate the Effect of Ticagrelor versus Placebo in Reducing the Rate of Vaso-Occlusive Crises in Paediatric Patients with Sickle Cell Disease (HESTIA3)

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 25 Jul 2022

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At a glance

  • Drugs Ticagrelor (Primary)
  • Indications Vaso-occlusive crisis
  • Focus Therapeutic Use
  • Acronyms HESTIA3
  • Sponsors AstraZeneca
  • Most Recent Events

    • 18 Jul 2022 Primary endpoint (Number of VOCs) has not been met according to the results published in the Blood
    • 18 Jul 2022 Results assessing the efficacy and safety of the reversible P2Y12 inhibitor ticagrelor versus placebo in preventing vaso-occlusive crises in pediatric patients with sickle cell disease published in the Blood
    • 24 Dec 2021 This trial has been completed in Belgium (End date - 2020-08-13), according to European Clinical Trials Database record.
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