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Phase 3, Open-Label, 4-Cohort Study of Nogapendekin Alfa Inbakicept in Combination With Current Standard of Care as First-Line Treatment for Patients With Advanced or Metastatic Non-Small Cell Lung Cancer

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Trial Profile

Phase 3, Open-Label, 4-Cohort Study of Nogapendekin Alfa Inbakicept in Combination With Current Standard of Care as First-Line Treatment for Patients With Advanced or Metastatic Non-Small Cell Lung Cancer

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 02 Feb 2026

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At a glance

  • Drugs Nogapendekin alfa inbakicept (Primary) ; Pembrolizumab (Primary) ; Carboplatin; Cisplatin; Paclitaxel; Pemetrexed
  • Indications Non-small cell lung cancer
  • Focus Therapeutic Use
  • Acronyms QUILT2.023
  • Sponsors Altor BioScience Corporation; ImmunityBio

Most Recent Events

  • 14 Jan 2026 According to an ImmunityBio media release, the Saudi Food and Drug Authority (SFDA) has granted accelerated approval of ANKTIVA (nogapendekin alfa inbakicept) for use in combination with immune checkpoint inhibitors for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose disease has progressed following standard-of-care therapy.
  • 16 Oct 2025 Planned End Date changed from 1 Apr 2026 to 31 Dec 2026.
  • 16 Oct 2025 Planned primary completion date changed from 1 Oct 2025 to 31 Oct 2026.

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