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A Phase I/II, Open-label, Dose Escalation and Expansion Study to Evaluate Safety, Tolerability, and Clinical Activity of the Antibody-Drug Conjugate GSK2857916 Administered in Combination with Lenalidomide Plus Dexamethasone (Arm A), or Bortezomib Plus Dexamethasone (Arm B) in Participants with Relapsed / Refractory Multiple Myeloma – DREAMM-6

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Trial Profile

A Phase I/II, Open-label, Dose Escalation and Expansion Study to Evaluate Safety, Tolerability, and Clinical Activity of the Antibody-Drug Conjugate GSK2857916 Administered in Combination with Lenalidomide Plus Dexamethasone (Arm A), or Bortezomib Plus Dexamethasone (Arm B) in Participants with Relapsed / Refractory Multiple Myeloma – DREAMM-6

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 21 Mar 2025

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At a glance

  • Drugs Belantamab mafodotin (Primary) ; Aciclovir; Antivirals; Bortezomib; Bortezomib; Dexamethasone; Dexamethasone; Lenalidomide
  • Indications Multiple myeloma
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms DREAMM-6
  • Sponsors GlaxoSmithKline; GlaxoSmithKline Research & Development; GSK

Most Recent Events

  • 20 May 2024 Status changed from active, no longer recruiting to completed.
  • 12 Dec 2023 Results (n=45, final analysis cutoff date (Feb 28, 2023), the median age was 68 (36-80) years) assessing safety and efficacy analysis of DREAMM-6 Trial Arm-a, were presented at the 65th American Society of Hematology Annual Meeting and Exposition.
  • 22 May 2023 Planned End Date changed from 29 Feb 2024 to 28 Feb 2024.

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