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A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter, International Study of Osimertinib as Maintenance Therapy in Patients With Locally Advanced, Unresectable EGFR Mutation-positive Non-Small Cell Lung Cancer (Stage III) Whose Disease Has Not Progressed Following Definitive Platinum-based Chemoradiation Therapy (LAURA)

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Trial Profile

A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter, International Study of Osimertinib as Maintenance Therapy in Patients With Locally Advanced, Unresectable EGFR Mutation-positive Non-Small Cell Lung Cancer (Stage III) Whose Disease Has Not Progressed Following Definitive Platinum-based Chemoradiation Therapy (LAURA)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 28 May 2025

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At a glance

  • Drugs Osimertinib (Primary)
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms LAURA
  • Sponsors AstraZeneca; AstraZeneca AB

Most Recent Events

  • 21 May 2025 According to an AstraZeneca media release, TAGRISSO (Osimertinib) has been conditionally approved in Canada based on the results of this trial, for the treatment of patients with locally advanced, unresectable (stage III) non-small cell lung cancer (NSCLC) whose tumours have EGFR exon 19 deletions or exon 21 (L858R) substitution mutations (either alone or in combination with other EGFR mutations) and whose disease has not progressed during or following platinum based chemoradiation therapy.
  • 25 Mar 2025 Results presented in an AstraZeneca media release
  • 25 Mar 2025 According to an AstraZeneca media release, data from this trial presented at the European Lung Cancer Congress (ELCC) 2025, 26 to 29 March.

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