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Impact of the Combination of Durvalumab (MEDI4736) Plus Olaparib (AZD2281) Administered Prior to Surgery in the Molecular Profile of Resectable Urothelial Bladder Cancer

Trial Profile

Impact of the Combination of Durvalumab (MEDI4736) Plus Olaparib (AZD2281) Administered Prior to Surgery in the Molecular Profile of Resectable Urothelial Bladder Cancer

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 06 Jun 2025

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At a glance

  • Drugs Durvalumab (Primary) ; Olaparib (Primary)
  • Indications Bladder cancer; Carcinoma; Squamous cell cancer
  • Focus Therapeutic Use
  • Acronyms NEODURVARIB

Most Recent Events

  • 30 Apr 2025 Results evaluating safety and efficacy of durvalumab plus olaparib presented at the 116th Annual Meeting of the American Association for Cancer Research.
  • 19 Feb 2022 Results evaluating the basal molecular profiles and their evolution under treatment with this combination, presented at the 2022 Genitourinary Cancers Symposium
  • 21 Sep 2020 Results assessing efficacy and safety of neoadjuvant combination of durvalumab plus olaparib in resectable urothelial bladder cancer, presented at the 45th European Society for Medical Oncology Congress

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