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KEYSTROKE: A Randomized Phase II Study of Pembrolizumab (KEYTRUDA) Plus Stereotactic Re-irradiation Versus SBRT Alone for Locoregionally Recurrent or Second Primary Head and Neck Carcinoma

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Trial Profile

KEYSTROKE: A Randomized Phase II Study of Pembrolizumab (KEYTRUDA) Plus Stereotactic Re-irradiation Versus SBRT Alone for Locoregionally Recurrent or Second Primary Head and Neck Carcinoma

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 23 Jan 2026

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At a glance

  • Drugs Pembrolizumab (Primary)
  • Indications Head and neck cancer; Squamous cell cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms KEYSTROKE

Most Recent Events

  • 20 Jan 2026 Status changed from recruiting to active, no longer recruiting.
  • 07 Feb 2023 Planned End Date changed from 1 Jul 2026 to 1 Jul 2029.
  • 07 Feb 2023 Planned primary completion date changed from 1 Jul 2024 to 1 Jul 2027.

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