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A Phase 2, Open-Label, Multicenter, Dose-Escalation and Expansion Study of Venetoclax in Combination With Pomalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma

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Trial Profile

A Phase 2, Open-Label, Multicenter, Dose-Escalation and Expansion Study of Venetoclax in Combination With Pomalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 02 Mar 2022

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At a glance

  • Drugs Dexamethasone (Primary) ; Pomalidomide (Primary) ; Venetoclax (Primary)
  • Indications Multiple myeloma
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors AbbVie

    • Most Recent Events

    • 30 May 2021 This trial has been completed in Spain (Global end date: 18 June 2020).
    • 08 Nov 2019 Planned primary completion date changed from 20 Aug 2020 to 22 Jan 2021.
    • 19 Mar 2019 According to an AbbVie media release, the company announced that the U.S. Food and Drug Administration (FDA) has placed a partial clinical hold on all clinical trials evaluating venetoclax for the investigational treatment of multiple myeloma. The partial clinical hold follows a review of data from BELLINI study.As a result of this action, no new patients should be enrolled in any studies of venetoclax for multiple myeloma until a further analysis of the data is completed.

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