Trial Profile

Phase 1 Study of Combination Osimertinib, Platinum, Etoposide for Patients With Metastatic EGFR Mutant Lung Cancers With Concurrent RB1 and TP53 Alterations

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 16 Jul 2024

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At a glance

Drugs Carboplatin (Primary) ; Cisplatin (Primary) ; Etoposide (Primary) ; Osimertinib (Primary)
Indications Non-small cell lung cancer
Focus Adverse reactions

03 Jul 2024 Planned End Date changed from 1 Jun 2024 to 1 Jun 2025.
03 Jul 2024 Planned primary completion date changed from 1 Jun 2024 to 1 Jun 2025.
04 Jun 2024 Results hypothesizing that if small cell directed chemotherapy is utilized prior to histologic transformation in EGFR/TP53/RB1 mutant LC, we may eradicate any pre-existing small cell clones, prevent small cell histologic transformation, and improve patient outcomes were presented at the 60th Annual Meeting of the American Society of Clinical Oncology.

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