A Phase 1, First-in-Human, Open-Label Study of the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-64619178, an Inhibitor of Protein Arginine Methyltransferase 5 (PRMT5) in Subjects With Advanced Cancers

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 11 Dec 2024

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At a glance

Drugs Onametostat (Primary)
Indications Adenoid cystic carcinoma; B-cell lymphoma; Myelodysplastic syndromes; Non-Hodgkin's lymphoma; Prostate cancer; Solid tumours; Uveal melanoma
Focus Adverse reactions; First in man
Sponsors Janssen Research & Development

Most Recent Events

09 Dec 2024 Planned End Date changed from 31 Dec 2024 to 31 Dec 2025.
09 Dec 2024 Planned primary completion date changed from 31 Dec 2024 to 31 Dec 2025.
10 Oct 2023 Planned End Date changed from 29 Dec 2023 to 31 Dec 2024.

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