A Global Randomized Multicenter Phase 3 Trial of JCAR017 Compared to Standard of Care in Adult Subjects With High-risk, Second-line, Transplant-eligible Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphomas (TRANSFORM)
Latest Information Update: 20 Jan 2025
At a glance
- Drugs Lisocabtagene-maraleucel (Primary) ; Carboplatin; Carmustine; Cisplatin; Cyclophosphamide; Cytarabine; Dexamethasone; Etoposide; Fludarabine; Gemcitabine; Ifosfamide; Melphalan; Rituximab
- Indications B-cell lymphoma; Diffuse large B cell lymphoma; Follicular lymphoma; Non-Hodgkin's lymphoma; T-cell lymphoma
- Focus Registrational; Therapeutic Use
- Acronyms TRANSFORM
- Sponsors Celgene Corporation
- 13 Jan 2025 According to a Bristol Myers Squibb media release, company announced Health Canada approval of Breyanzi (lisocabtagene maraleucel) for the treatment of adult patients with diffuse large B-cell lymphoma (DLBCL). The Health Canada approval is supported by results from the pivotal Phase 3 TRANSFORM trial.
- 09 Dec 2024 According to a Bristol Myers Squibb media release, data from this study were presented at the 66 th American Society of Hematology (ASH) Annual Meeting and Exposition in San Diego, California.
- 19 Nov 2024 According to a Bristol Myers Squibb media release, results from this trial will be presented at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition, to be held from December 7 to 10 in San Diego, California.