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A Global Randomized Multicenter Phase 3 Trial of JCAR017 Compared to Standard of Care in Adult Subjects With High-risk, Second-line, Transplant-eligible Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphomas (TRANSFORM)

Trial Profile

A Global Randomized Multicenter Phase 3 Trial of JCAR017 Compared to Standard of Care in Adult Subjects With High-risk, Second-line, Transplant-eligible Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphomas (TRANSFORM)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 20 Jan 2025

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At a glance

  • Drugs Lisocabtagene-maraleucel (Primary) ; Carboplatin; Carmustine; Cisplatin; Cyclophosphamide; Cytarabine; Dexamethasone; Etoposide; Fludarabine; Gemcitabine; Ifosfamide; Melphalan; Rituximab
  • Indications B-cell lymphoma; Diffuse large B cell lymphoma; Follicular lymphoma; Non-Hodgkin's lymphoma; T-cell lymphoma
  • Focus Registrational; Therapeutic Use
  • Acronyms TRANSFORM
  • Sponsors Celgene Corporation
  • Most Recent Events

    • 13 Jan 2025 According to a Bristol Myers Squibb media release, company announced Health Canada approval of Breyanzi (lisocabtagene maraleucel) for the treatment of adult patients with diffuse large B-cell lymphoma (DLBCL). The Health Canada approval is supported by results from the pivotal Phase 3 TRANSFORM trial.
    • 09 Dec 2024 According to a Bristol Myers Squibb media release, data from this study were presented at the 66 th American Society of Hematology (ASH) Annual Meeting and Exposition in San Diego, California.
    • 19 Nov 2024 According to a Bristol Myers Squibb media release, results from this trial will be presented at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition, to be held from December 7 to 10 in San Diego, California.

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